Nitroglycerin: Topical Treatment for Anal Fissures and GI-Related Pain
What Is Nitroglycerin Used for in Gastroenterology?
Nitroglycerin is most commonly known as a cardiovascular medication used to treat angina. In gastroenterology, however, it serves a valuable off-label purpose—treating chronic anal fissures. Applied topically, Nitroglycerin helps relax the internal anal sphincter, improve blood flow to the fissure site, and reduce pain caused by muscle spasms and tension.
As a compounded therapy, Nitroglycerin offers a non-surgical treatment path for patients with painful, persistent fissures, especially those resistant to conventional remedies.
How Compounded Nitroglycerin Works
When formulated as a rectal cream or ointment, Nitroglycerin acts locally to lower sphincter pressure, allowing the surrounding tissue to heal. The medication is usually applied in small amounts directly to the anal canal, with many patients experiencing relief from spasm-induced pain within days.
At King’s Pharmacy and Compounding Center, we prepare Nitroglycerin formulations based on your provider’s specifications, ensuring appropriate concentration and compatibility with soothing agents like lidocaine or aloe vera.
“Nitroglycerin cream is a proven, targeted solution for anal fissures—often preventing the need for surgery.”
Benefits of Topical Nitroglycerin for GI Use
- Relieves spasms and pain from anal fissures
- Promotes blood flow to damaged tissue
- Offers a non-invasive, outpatient solution
- Customized concentrations to minimize side effects
Nitroglycerin therapy has demonstrated high success rates when used consistently. Because it’s locally applied, systemic absorption is minimal—though patients should still follow their provider’s directions carefully.
FAQs About Nitroglycerin
Typically, a pea-sized amount is applied to the anal area two to three times daily. Always follow your provider’s instructions and wash hands thoroughly after use.
Many patients report symptom relief within one week, though complete healing may take several weeks of continued application.
Some patients experience headaches, dizziness, or lightheadedness. These effects are usually mild and improve with dosage adjustments.
Yes. It is often compounded with lidocaine for pain relief or other agents to enhance comfort and compliance.
