Nifedipine: A Gastroenterological Approach to Anal Fissure Relief
What Is Nifedipine in GI Medicine?
Nifedipine is a calcium channel blocker most commonly used for treating hypertension and angina. However, in gastroenterology, it’s frequently compounded into topical creams or ointments to treat chronic anal fissures. When applied rectally, Nifedipine relaxes the smooth muscle of the internal anal sphincter, increasing blood flow and promoting healing in the affected tissue.
This localized use offers a highly effective, non-surgical option for patients suffering from painful fissures—especially when standard conservative therapies have failed.
Compounded Nifedipine for Anal Fissures
At King’s Pharmacy and Compounding Center, we prepare customized Nifedipine formulations based on each patient’s prescription. Compounded Nifedipine creams are typically combined with soothing agents like lidocaine to provide immediate pain relief while supporting long-term tissue repair.
Our pharmacists compound rectal Nifedipine in various concentrations and bases (cream or ointment) depending on patient sensitivity, duration of use, and physician preference.
“Topical Nifedipine offers targeted relief for anal fissures—without the systemic effects of oral medications.”
Benefits of Rectal Nifedipine Therapy
- Reduces internal sphincter pressure
- Promotes healing of fissures
- Alleviates pain and spasms
- Avoids need for surgery in many cases
Clinical studies have shown that topical Nifedipine achieves healing rates of up to 90% when used consistently under a provider’s supervision. It’s often favored over surgery for its low side-effect profile and ease of use.
FAQs About Nifedipine
Apply a small amount to the anal canal 2–3 times daily, as prescribed. Wash hands before and after use and follow your doctor’s instructions closely.
Many patients begin to notice reduced pain within a few days. Full healing can take 4–6 weeks of consistent application.
Yes. It’s often compounded with lidocaine or hydrocortisone for enhanced symptom control.
Side effects are rare but may include mild irritation or dizziness if absorbed systemically. Always report new symptoms to your provider.
